談到益生菌，想必很多人的直覺會聯想到乳酸菌（Lactobacillus）或是雙岐桿菌（Bifidobacterium），此兩株菌株被列為是腸道好菌，充足的菌數定植於腸道中有助於提升腸胃道健康，並維護腸道環境，以及具有多項提升宿主健康之效益。

不過隨著科學研究的進展，近幾年更多科學家與學者朝向次世代益生菌進行研究，找出更多有益健康的菌種。次世代益生菌不同於第一代的益生菌種，第一代益生菌多被食用多年，長年被用來當作食品或補充品，而次世代益生菌無被長期食用的歷史，而且是近幾年才開始大量研究。

參考文獻:

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3. Wang, L., Tang, L., Feng, Y., Zhao, S., Han, M., Zhang, C., ... & Zhang, Z. (2020). A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice. Gut, 69(11), 1988-1997.

4. Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., ... & Cani, P. D. (2019). Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature medicine, 25(7), 1096-1103.